From: North. Take Interstate 95 South, follow signs to Tri-Borough Bridge. Follow signs for Manhattan. Get on the FDR Drive South.Take the FDR Drive to the 49th Street exit. Follow 49th street to the hotel. The Best Western Hospitality House is located on the right between 3rd Avenue and Lexington Avenue. From: South. Take Interstate 95 North/George Washington Bridge, follow the signs for Harlem River/FDR Drive. Take the Harlerm River Drive to the FDR Drive. Exit the FDR Drive at the 49th Street exit. Follow 49th street to the hotel. The Best Western Hospitality House is located on the right between 3rd Avenue and Lexington Avenue. From: East. Take Queens-Midtown Tunnel, make a right on Third Avenue to 49th Street. Make left on 49th street, the Best Western Hospitality House. From: West. Take the Lincoln Tunnel, take 34th Street. Take 34th to 3rd Avenue. Take 3rd Avenue to 49th Street. Make a left on to 49th Street. The Best Western Hospitality House is located on the right between 3rd Avenue and Lexington Avenue.